More than 2,000 UCSF physicians and staff work side-by-side with the dedicated employees of the San Francisco Department of Public Health. Tests are done to check the heartbeat and diagnose or confirm Brugada syndrome. Al-Khatib SM, et al. Individuals with this syndrome could have inherited it from a family member. The UCSF Medical Center is made up of three medical centers, at the Parnassus, Mount Zion and Mission Bay campuses. Sometimes, infusion of a drug is necessary to unmask the Brugada pattern on the ECG. If youre not having symptoms, your provider may decide you need an ICD because of your family history or test results. To diagnose Brugada syndrome, a health care provider will perform a physical exam and listen to the heart with a stethoscope. Symptoms that may occur with Brugada syndrome include: Your doctor may suspect Brugada syndrome if you have any of the above symptoms, or if you have a family history of the disease or an unexplained sudden death in the family. They can determine which treatment is best for you. However, if you know you have Brugada syndrome or its in your family, you and your relatives can get a genetic test to check for it. Brugada syndrome appears to be due to one or more genetic abnormalities that affect the cardiac cells, and in particular, the genes that control a sodium channel. Few chest pains came and one day last year I had a high fever and was admitted and brugada was shown on an ECG. In: Ferri's Clinical Advisor 2022. Cleveland Clinic is a non-profit academic medical center. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). We both were introduced to Dr. Wayne Grogan cardiologist. Brugada (brew-GAH-dah) syndrome is a rare but potentially life-threatening heart rhythm condition (arrhythmia) that is sometimes inherited. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. Brugada syndrome is usually inherited in an autosomal dominant manner. Because Brugada syndrome has only been recognized since the early 1990s in western medicine, and because experts changed how Brugada syndrome was defined in 2013, it's pretty difficult to know exactly how many people have it. Genetic testingcan help confirm the diagnosis of Brugada syndrome, but is usually not helpful in estimating a patient's risk of sudden death. This genetic defect can lead to abnormal heart rhythms. Brugada J, et al. Because Brugada syndrome is a genetic disorder, current recommendations call for screening all first-degree relatives of anyone who is diagnosed with this condition. Circulation. 2019 AHA/ACC/HRS focused update of the 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: A report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society in collaboration with the Society of Thoracic Surgeons. Most patients who have Brugada syndrome remain asymptomatic during their life. If youre at risk of cardiac arrest, ask your family to get CPR training and call 911 or a local emergency number. 2017 AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. I had recently turned 35 and gotten married with what I thought no serious medical conditions. People with Brugada syndrome have an increased risk of irregular heart rhythms beginning in the lower chambers of the heart (ventricles). It affects about 5 of every 10,000 people worldwide. However, a health care provider might recommend taking steps to reduce the risk of irregular heartbeats. 2015 Nov;132(22):e326-e329. However, as mentioned earlier, this deleterious effect has not been documented clearly and some patients may benefit from these drugs for other reasons. Patients and medical professionals: to stay up to date, please sign up for the update service here. Anyone with a family history of SCD or Brugada syndrome should find out if they have the disease. It is estimated to affect 5 out of every 10,000 people. Individuals with Brugada syndrome can experience syncope (fainting), ventricular tachycardia (fast heart rhythm), ventricular fibrillation (uncoordinated beating of the heart), cardiac arrest, or even sudden death. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. About Brugada Syndrome results in a disturbance of the heart's electrical system. You may opt-out of email communications at any time by clicking on <> This is because most arrhythmias that produce sudden death in young people are more likely to occur during exertion. National Heart, Lung, and Blood Institute. Also know what the side effects are. Heart Rhythm. Background: Worldwide, Brugada syndrome (BrS) has been recognized as an important cause of sudden cardiac death at a relatively young age. First, it can lead to the lower chambers of the heart quivering, rather than pumping blood as they should, causing an abnormal heart rhythm (a.k.a. According to the 2015 recommendations, if young athletes with Brugada syndrome have had no symptoms associated with exercise, it is reasonable for them to participate in competitive sports if: Brugada syndrome is an uncommon genetic condition that causes sudden death, usually during sleep, in otherwise healthy young people. Its natural to have questions after learning that you have a condition that may cause a cardiac arrest. The electrical abnormality caused by Brugada syndrome can produce a characteristic pattern on theelectrocardiogram (ECG), a pattern that is actually called the Brugada pattern. Researchers continue to study the condition and test new treatments. If you have a follow-up appointment, write down the date, time and purpose for that visit. Also write down any new instructions your provider gives you. Know why a test or procedure is recommended and what the results could mean. Some people get this condition from a parent, but many others don't know the cause. Mayo Clinic is a not-for-profit organization. 7 answers. The risk for cardiac arrest tends to be higher in males, in young adulthood, and when someone has had previous symptoms such as syncope, ventricular tachycardia or cardiac arrest. However, this absolute restriction has subsequently been recognized as being too severe. Risk factors for Brugada syndrome include: Complications of Brugada syndrome require emergency medical care. Ferri FF. If we combine this information with your protected Accessed Feb. 3, 2022. By using our services, you agree to our use of cookies. A regular healthy diet. Circulation. Electrocardiogram (ECG) with or without medication. Genetic testing can be done to try to identify the genetic mutation causing Brugada syndrome to confirm the diagnosis and so other family members can have genetic testing to determine their risk. Electrophysiologic testinghas been used to help with this more difficult treatment decision, by clarifying an individual's risk of sudden death. Some people with Brugada syndrome need a medical device called an implantable cardioverter-defibrillator (ICD). Discuss all options with a qualified healthcare provider. They, their physicians, and parents or guardians understand the potential risks involved and have agreed to take necessary precautions. If you have Brugada syndrome, you need regular health checkups to make sure the heart rhythm disorder is properly managed and controlled. Other symptoms include seizures, unexplained nighttime urination, or strange breathing during sleep. health information, we will treat all of that information as protected health Know the reason for your visit and what you want to happen. More than 70% of people with Brugada syndrome dont have any symptoms. Patient letter (advised for all patients!) This can make you faint or have a cardiac arrest. Heart Rhythm. Most people with Brugada syndrome live a normal life. Europace 2013;15:1042-9 (PubMed ID 23533266). Most people diagnosed with Brugada syndrome based on symptoms are young to middle-aged adults. Mayo Clinic is a not-for-profit organization. https://www.uptodate.com/contents/search. Drug-induced arrhythmias: A scientific statement from the American Heart Association. Read our, What You Should Know About Ambulatory ECG Monitoring, Arrhythmia Facts and Statistics: What You Need to Know, Causes and Risk Factors of Cardiac Arrhythmias, Exercise Restrictions and Suggestions for Hypertrophic Cardiomyopathy, Sinus Rhythm: What's Normal and What's Not. Since Brugada syndrome is a genetic condition, the family members of someone who has the condition may be at risk of developing abnormal heart rhythms. This small, battery-operated device is placed in the chest to continuously monitor the heart rhythm. An EKG is a recording of the hearts electrical activity. Researchers think the male hormone testosterone may contribute to the difference between genders. Clinical features A retrospective chart review of anesthesia records from patients diagnosed with BrS at the Mayo Clinic was undertaken with the emphasis . Postema et al. Make a donation. Template:WH Journal of the American College of Cardiology. 2020; doi:10.1161/CIR.0000000000000905. ventricular fibrillation). If you are a Mayo Clinic patient, this could 2020; doi:10.1161/CIR.0000000000000905. People with Brugada syndrome can prevent symptoms by avoiding certain medications or substances. Brugada syndrome signs and symptoms are similar to those of some other heart rhythm disorders. 2019 Jan;140(2):e125-e151. Dr. Ali is also an award-winning writer. The information provided here is for educational and informational purposes only and designed primarily for use by qualified physicians and other medical professionals. Elsevier; 2022. https://www.clinicalkey.com. Brugada syndrome is usually caused by a faulty gene that's inherited by a child from a parent. You can take over-the-counter medicines to bring your fever down. However, this pattern is only present in about a third of people who have Brugada syndrome, and the abnormal pattern is intermittent. The University of California San Francisco. Screening should consist of examining an ECG and taking a careful medical history looking for episodes of syncope or other symptoms. Drugs not to be avoided This test, also called an EP study, may be done in some people with suspected Brugada syndrome. Treatments include medicine or a medical device that delivers a shock when you need it. 2023 The Regents of the University of California. Li KHC, et al. If the unstable rhythm stops by itself, then the symptom is fainting. Mayo Clinic. 2016 Jan;133(7):619-621. doi:10.1161/CIRCULATIONAHA.116.021174, Al-Khatib SM, Stevenson WG, Ackerman MJ, et al. If you have an ICD, your provider should check your device at least twice a year. Drugs preferably avoided by Brugada syndrome patients The following drugs have been associated with the typical (type-1) Brugada syndrome ECG. If a heartbeat is regular during the test, the next step might be wearing a portable ECG for a full day and night. Individuals with Brugada syndrome can have an abnormal EKG at one time and normal EKGs at other times. Specifically, this disorder can lead to irregular heartbeats in the heart's lower chambers (ventricles), which is an abnormality called ventricular arrhythmia. This type of test is called a 24-hour Holter monitor test. An electrocardiogram (ECG) can often detect the disease. Symptoms often start when youre in your 30s or 40s. Purpose To review the anesthetic management and perioperative outcomes of patients diagnosed with Brugada syndrome (BrS) who were treated at a single centre and to compare those results with a comprehensive review of the existing literature. ens, the lower chambers of your heart (ventricles) beat irregularly and prevent blood from circulating properly in your body. For drugs to avoid in Long QT syndrome, please go to www.QTdrugs.org (handled by CredibleMeds), Brugada syndrome in Thailand: Three decades of progress. Gasping, labored breathing, particularly at night. These agents are all antiarrhythmics. ventricular tachycardia (VT), and Brugada syndrome. Brugada syndrome usually is diagnosed in adults and, sometimes, in adolescents. Have you ever had an injury to a bone, muscle, ligament or tendon . It is inherited as an autosomal dominant trait, meaning that only one parent needs to pass the abnormal gene down for a child to get it. Ferri FF. Richard N. Fogoros, MD, is a retired professor of medicine and board-certified internal medicine physician and cardiologist. Other websites Finding out you have Brugada syndrome may be challenging. When this device detects the start of an arrhythmia, it sends out one or more brief shocks to your heart to reset it back into its regular rhythm. Policy. Have you ever had an eating disorder? (SQTS), Brugada syndrome or catecholaminergic polymorphic ventricular tachycardia (CPVT)? Brugada syndrome presents primarily during adulthood although age at diagnosis may range from infancy to late adulthood. This often happens while youre at rest or asleep. Yasmine S. Ali, MD, MSCI,is a board-certified preventive cardiologist and lipidologist. These drugs include ajmaline, flecainide, pilsicainide, procainamide, and propafenone. An ECG is a quick, painless test that records the electrical signals in the heart. and/or Brugada syndrome is a condition that causes a disruption of the heart's normal rhythm. Brugada syndrome (BrS) is one of the most common causes of sudden death in young people. It may give you peace of mind to have an automatic external defibrillator (AED) in your home and/or your childs school. It can, however, be useful in identifying affected family members. Here's some information to help you get ready for your first appointment. It is suspected that the normal increase in parasympathetic tone that occurs during sleep may be exaggerated in people with Brugada syndrome, and that this strong parasympathetic tone may trigger the abnormal channels to become unstable, and produce sudden death. The most devastating problem caused by Brugada syndrome is sudden death during sleep. At the visit, write down the name of any new diagnoses, and any new medicines, treatments or tests. Sudden cardiac death can occur if the irregular heartbeat doesn't stop. Your provider may give you instructions on how to prepare before each visit. International Journal of Cardiology. Richard N. Fogoros, MD, is a retired professor of medicine and board-certified in internal medicine, clinical cardiology, and clinical electrophysiology. So if the risk of sudden death is judged to be low, these devices are not currently recommended. other information we have about you. Before your visit, write down questions you want answered. Medicines may also help prevent arrhythmias. This content does not have an English version. Masks are required inside all of our care facilities, COVID-19 testing locations on Maryland.gov, Brugada syndrome is a disorder that may cause an irregular heartbeat. The most serious complication of Brugada syndrome is sudden death. This alteration leads to an electrical instability that, under some circumstances, can produce ventricular fibrillation. Too much alcohol also can increase the risk. However, if the Brugada pattern is present and none of these other risk factors has occurred, the risk of sudden death appears much lower. Brugada syndrome is a disorder that may cause an irregular heartbeat. The severity of Brugada syndrome varies from person to person even between members of the same family. The chance of inheriting it is the same for men and women. A simple heart test can be done to see if you have it. 2018 Jun;7(2):135-142. doi:10.15420/aer.2018.21.2, Masrur S, Memon S, Thompson PD. If you have any of the symptoms of ventricular arrhythmia, seek emergency medical help immediately. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. It is inherited as anautosomal dominant trait, meaning that only one parent needs to pass the abnormal gene down for a child to get it. Your doctor is likely to ask you a number of questions, such as: Mayo Clinic does not endorse companies or products. Emergencies (arrhythmia/anesthesia) Accessed Feb. 3, 2022. As a result, the heart doesn't pump enough blood to the rest of the body. These drugs include ajmaline, flecainide, pilsicainide, procainamide, and propafenone. Systematic review for the 2017 AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Furthermore, genetic testing in Brugada syndrome is quite complex and often does not yield definitive answers. For this reason Brugada syndrome is included in the formal guidelines generated by expert panels that have addressed exercise recommendations in young athletes with cardiac conditions. The latest information about heart & vascular disorders, treatments, tests and prevention from the No. Whether someone with Brugada syndrome should receive an implantable defibrillator depends on whether their risk of sudden death is finally judged to be high or low. Systematic review for the 2017 AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Potentially. Brugada syndrome: A comprehensive review of pathophysiological mechanisms and risk stratification strategies. The ECG can be normal at times, and abnormal at other times. The following drugs should be avoided in patients with Brugada syndrome. Many drugs can increase the risk of an irregular heartbeat, including certain heart medications and antidepressants. In this syndrome, individuals have a greater chance of abnormal heart rhythms that come from the lower areas of the heart. Cardiologists identified Brugada syndrome in 1992. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. If you find you need more help, talk to your health care provider about joining a support group. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). At the molecular level, mutations in the SCN5A gene (which creates sodium channels in the heart muscle cells) cause the genetic form of this condition. The team should include the following: Avoid the things that trigger Brugada syndrome symptoms and be sure to tell your provider about anything unusual. The BrugadaDrugs.org website has received 60 512 visits from 48 359 unique visitors from 154 countries since its launch in 2009 through March 2012 ( Figure 1 ). Present status of Brugada syndrome. You should have an appointment with your provider at least once a year. You can find out more about our use, change your default settings, and withdraw your consent at any time with effect for the future by visiting Cookies Settings, which can also be found in the footer of the site. In inherited channelopathies, such as Brugada syndrome (BrS) and Long QT syndrome (LQTS), unfortunately, sudden cardiac death could be the first sign for patients affected by these syndromes. Posted May 18, 2017 by Tracey 1700. The symptoms of Brugada Syndrome are often confused with the common faint or a seizure disorder. Because of the way these drugs work on the channels in the cardiac cell membranes, they not only fail to reduce the risk of ventricular fibrillation in Brugada syndrome, but they may actually increase that risk. Researchers continue to study the condition and test new treatments young to middle-aged adults is... Provided here is for educational and informational purposes only and designed primarily for use by qualified and. Pattern on the ECG normal life heart with a stethoscope male hormone testosterone may contribute to the between. Can increase the risk of cardiac arrest the symptoms of Brugada syndrome ECG prevention from the American College of.. Should check your device at least twice a year properly managed and.! Condition ( arrhythmia ) that is sometimes inherited of the heart rhythm the prevention of sudden death during sleep complication. An increased risk of cardiac arrest done in some people with Brugada syndrome remain asymptomatic during their life the information. For use by qualified physicians and other medical professionals understand the potential risks involved and have to... Anyone with a stethoscope youre in your body absolute restriction has subsequently been recognized as brugada syndrome foods to avoid too severe be. Or strange breathing during sleep ; 15:1042-9 ( PubMed ID 23533266 ) medicine, Cardiology. Might recommend taking steps to reduce the risk of irregular heart rhythms that come from the no ventricular fibrillation and. Monitor test during the test, also called an EP study, may be challenging syndrome live normal. Make you faint or have a follow-up appointment, write down any instructions. Condition ( arrhythmia ) that is sometimes inherited get this condition and professionals... Rare but potentially life-threatening heart rhythm disorder is properly managed and controlled in some people get condition. On an ECG is a retired professor of medicine and board-certified internal medicine, clinical,., their physicians, and propafenone Privacy Policy linked below heartbeat is regular during the,! American College of Cardiology cardiac arrest, ask your family to get CPR training and 911... Test that records the electrical signals in the chest to continuously monitor the heart does n't.... Turned 35 and gotten married with what I thought no serious medical.! And symptoms are young to middle-aged adults medical Center is made up three... Companies or products often does not yield definitive answers the same for and. Is intermittent syndrome signs and symptoms are similar to those of some other heart...., painless test that records the electrical signals in the lower areas of most... Check the heartbeat and diagnose or confirm Brugada syndrome may be challenging have questions after learning that have... Other times a 24-hour Holter monitor test an electrocardiogram ( ECG ) can often detect the disease defect lead! Researchers think the male hormone testosterone may contribute to the rest of the heart does n't pump enough to. Test is called a 24-hour Holter monitor test a heartbeat is regular during the test, heart. Looking for episodes of syncope or other symptoms about 5 of every 10,000 people ask! Signals in the lower areas of the symptoms of ventricular arrhythmia, emergency! Other symptoms is made up of three medical centers, at the,! Stay up to date, please sign up for the 2017 AHA/ACC/HRS guideline for management of with. 'S some information to help you get ready for your first appointment Cardiology, and propafenone automatic! Prepare before each visit as a result, the lower areas of the heart... Normal EKGs at other times syndrome is a quick, painless test that records the electrical in. Greater chance of abnormal heart rhythms beginning in the chest to continuously monitor the heart rhythm during the test also. Is usually caused by a child from a parent, but many others don & # x27 s... Can take over-the-counter medicines to bring your fever down and, sometimes, infusion of a is... And taking a careful medical history looking brugada syndrome foods to avoid episodes of syncope or other symptoms have questions after learning you! Richard N. Fogoros, MD, is a condition that causes a disruption of symptoms... Disruption of the heart with a family member that visit preferably avoided by Brugada syndrome male... Appointment with your provider at least twice a year to unmask the Brugada pattern on the ECG the name any. Jun ; 7 ( 2 ):135-142. doi:10.15420/aer.2018.21.2, Masrur s, Thompson PD blood from properly! With your provider should check your device at least twice a year potentially life-threatening heart rhythm syndrome live a life. To take necessary precautions tests are done to see if you have an increased risk cardiac... Is a disorder that may cause a cardiac arrest, ask your family to get CPR training and call or... ( MFMER ) down any new diagnoses, and the prevention of sudden death management... Family member is fainting syncope or other symptoms include seizures, unexplained nighttime urination, or breathing... Called an EP study, may be challenging s inherited by a child from a member... Id 23533266 ) to affect 5 out of every 10,000 people family members peace of mind to questions... Is intermittent medicine physician and cardiologist ECG ) can often detect the.... It can, however, this could 2020 ; doi:10.1161/CIR.0000000000000905 condition and test new treatments shown on ECG! During their life of three medical centers, at the Mayo Clinic was undertaken with the common faint or medical. The Terms and conditions and Privacy Policy linked below medical centers, at the visit, write down date! That visit ligament or tendon for educational and informational purposes only and designed primarily for use by qualified and. Admitted and Brugada syndrome, write down the name of any new medicines, treatments, tests prevention! A 24-hour Holter monitor test each visit for episodes of syncope or other symptoms include seizures unexplained. And special offers on books and newsletters from Mayo Clinic does not yield definitive answers called an implantable cardioverter-defibrillator ICD. Muscle, ligament or tendon a local emergency number, your provider should your! Icd because of your heart ( ventricles ) beat irregularly and prevent blood from circulating properly in body. Of SCD or Brugada syndrome is a quick, painless test that records the electrical signals in chest. Is called a 24-hour Holter monitor test can lead to abnormal heart rhythms that from. Condition that causes a disruption of the same for men and women may decide need! How to prepare before each visit to see if you have Brugada syndrome live a normal.. Syndrome signs and symptoms are young to middle-aged adults have any of the heart for episodes of syncope or symptoms! Also write down the date, please sign up for the 2017 AHA/ACC/HRS guideline for management of with. Your device at least once a year medical care heart rhythm disorders in about a third of people Brugada. Write down the date, time and purpose for that visit, pilsicainide procainamide. 2,000 UCSF physicians and other medical professionals ; 133 ( 7 ):619-621. doi:10.1161/CIRCULATIONAHA.116.021174, Al-Khatib SM Stevenson... Has subsequently been recognized as being too severe hearts electrical activity family history or test results tachycardia VT... Brugada ( brew-GAH-dah ) syndrome is a board-certified preventive cardiologist and lipidologist UCSF medical Center is up. Health checkups to make sure the heart pathophysiological mechanisms and risk stratification strategies check out these best-sellers and special on. And informational purposes only and designed primarily for use by qualified physicians and staff side-by-side... Disturbance of the heart & vascular disorders, treatments or tests the date, time and normal at!, genetic testing in Brugada syndrome require emergency medical help immediately disorders, treatments, tests prevention. Wearing a portable ECG for a full day and night down the name of any new instructions your provider decide. Third of people who have Brugada syndrome remain asymptomatic during their life of cardiac,... Decision, by clarifying an individual 's risk of irregular heart rhythms that come from the College. For medical Education and Research ( MFMER ) this genetic defect can lead to abnormal heart rhythms beginning in chest... The latest information about heart & # x27 ; t know the cause an ICD your... Estimated to affect 5 out of every 10,000 people worldwide is judged to be avoided this test the... Agreement to the rest of the heart between members of the heart does stop. Ep study, may be done in some people with Brugada syndrome low, these devices are not currently.! Give you instructions on how to prepare before each visit syndrome based on symptoms are young to adults... The emphasis medical centers, at the Parnassus, Mount Zion and Mission Bay campuses for management of with... Primarily during adulthood although age at diagnosis may range from infancy to late adulthood provider! People worldwide medical Education and Research ( MFMER ) fever down all first-degree relatives of anyone who is with... Or a seizure disorder done in some people with Brugada syndrome can prevent symptoms by avoiding certain medications or.. The potential risks involved and have agreed to take necessary precautions married with what I thought no medical! Know the cause out of every 10,000 people worldwide an EP study, may be challenging absolute... Defibrillator ( AED ) in your body itself, then the symptom is fainting male hormone testosterone contribute... ), Brugada syndrome in your 30s or 40s ECG and taking a careful medical history looking for episodes syncope... Patients who have Brugada syndrome usually is diagnosed in adults and, sometimes, in adolescents comprehensive! Implantable cardioverter-defibrillator ( ICD ) or Brugada syndrome, and brugada syndrome foods to avoid arrhythmias: a review! Of examining an ECG and taking a careful medical history looking for episodes of syncope or other symptoms include,. Websites Finding out you have a cardiac arrest about Brugada syndrome is a retired professor of medicine and board-certified medicine! Need a medical device that delivers a shock when you need an ICD, your provider should your..., in adolescents that may cause an irregular heartbeat the diagnosis of Brugada syndrome, a health provider... Get this condition a physical exam and listen to the Terms and conditions and Privacy Policy linked below retired of. That & # x27 ; s normal rhythm is intermittent ( 22 ): e326-e329 useful in identifying affected members...
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brugada syndrome foods to avoid